A plant that is grown from seed, cloned, or regenerated is certain to require pruning at the ideal moments to encourage the development of the plant and ensure it is able to stay healthy. Cutting the lower branches is certain to increase airflow around the plant in the indoor environment; these cuttings can be used in the process of cloning. This is also able to benefit the top branches which are provided most of the light and should ensure a better harvest.
Cannabis plants used in regeneration require minor clipping throughout the process to make certain the area of regenerated growth is able to benefit from the energy from the plant. So, once the stem is able to show signs of regenerated growth, any of the lower branches which are covered by shade or appear weak should be removed. Ideally, you want to look at thinning out even at the top level branches to guarantee that only the most resilient and healthy growth is left in place.
A quality aspect of the process of regeneration is that several buds on the plants awaiting the further regenerating aren't always going to show signs of new development and therefore can be cut off and smoked. It is often possible to see a higher volume of material that is smokable if it is detected prior to the older flowers drying or dieing off in anticipation of the fresh vegetative growth.
In most cases you want to look at cutting a regenerated stem on two occasions. Initial trimming can take place as the plant begins to degenerate; collect those buds that have successfully sprouted and smoke if desired. A second trimming takes place to remove the lower branches and thin out the upper area to increase the chances of more buds getting regenerated.
A plant that isn't trimmed in any way is likely to result in a regeneration process that gives somewhat stemmy plants and aren't likely to offer enough buds with the overall production quite low.